Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2
Abstract Indoxyl sulfate (IS) accumulates in the body in chronic kidney disease (CKD).In the renal proximal tubules, IS excretion is mediated by OAT1/3 and ABCG2.These transporters are inhibited by some hypouricemic homend meatbox 3100h paslanmaz ?elik k?yma makinesi agents; OATs by probenecid and benzbromarone, ABCG2 by febuxostat and benzbromaron